![]() ![]() When you eat foods that contain folic acid, MTHFR converts it into methyl-folate (folate’s active form). MTHFR is a gene that provides the body with instructions for making a certain enzyme called methylenetetrahydrofolate reductase (MTHFR). 40% of us, making those of us with this gene mutation more vulnerable to toxic buildup. Genetic factors can include a mutation in the MTHFR gene, which affects approx. If Phase 2 detox is slow due to certain drugs, genetic factors or nutrient deficiency then these intermediary forms can build up and cause damage in your body. Phase 1 detox pathway neutralizes some toxins while converting others to forms that can then be processed by Phase 2. There are two major detoxification pathways inside the liver cells, which are called the Phase 1 and Phase 2 detoxification pathways. This is often the case, and likely the reason why so many users of Paleo-Plex and 100% Grass-Fed Bison Liver & Organ Complex report immediate increases to their energy levels and feelings of well-being.Did you know that curcumin inhibits phase 1 detoxification? (1) Now what exactly does this mean in terms of optimal guidelines on how to take curcumin? This may account for the rapid and profound impact that consuming liver and organ meats can have on one’s energy levels and subjective sense of clarity, mental energy, and stamina-if someone has never had the ability to properly methylate, and is then introduced to adequate nutrient levels for the processes to occur, then they can expect that everything is just going to work better! It’s rare for a single food to offer so many of the nutrients that are so key to metabolic processes in the body, but grass-fed bison liver checks all the boxes for methylation. Some folks with methylation polymorphisms report dramatic changes in their daily quality of life once their methylation issues are adequately addressed. The ability to methylate properly can impact our everyday quality of life! ![]() In short, methylation has an effect on our day-to-day living. Hormonal regulation (libido, muscle mass, energy) ![]() Genetic expression, DNA repair, and epigenetics (cell division, DNA&RNA synthesis, sense of youth and anti-aging)Įnergy and metabolism (stamina, endurance, mental clarity)ĭetoxification systems (toxin and histamine clearance)Ĭardiovascular health (longevity and athletic performance) Immunoregulation (impacts ability to fight colds, viruses, allergies, etc.) Neurotransmitter regulation & biosynthesis (impacts mental states like anxiety, depression, etc.) In the case that one has one or more of these polymorphisms, it becomes even more important for that individual to supply adequate amounts of each nutrient required for the methylation process.įortunately and coincidentally, liver from grass-fed ruminant species (and especially bison!) is incredibly rich in ALL (yes, ALL) of the nutrients required for optimum methylation.Īdequate ability to methylate has an impact on: These polymorphisms include MTHFR (the most notable and infamous of the polymorphisms), MTRR, CBS, COMT, and others. In other words, my ability to methylate may be very different from the reader’s ability to methylate. The human genome has many polymorphisms that can impact one’s ability to methylate. Most notably, many of the B vitamins (B2, B3, Pantothenic Acid B5, Pyridoxine B6, Folate B9, B12), zinc, choline, betaine, and taurine are all necessary for adequate methylation. These processes require many nutrients and vitamins to occur. Methylation is a necessary process for human beings to thrive! These methylation processes occur many times each second, in every cell in the human body. ![]() Methylation is an incredibly important process in the human body. ![]()
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